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Sua estrutura inclui uma substituio de aminocido na posio 3 e uma extenso de 13 aminocidos na extremidade N-terminal, modificaes que diminuem significativamente sua afinidade pelas protenas ligadoras de IGF (IGFBPs)

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In real physiology, the bigger driver is cellular decision-making

J Endocrinol (2014) 221(1):T116.10.1530/JOE-13-0414 64 DruckerDJ