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Inclusion criteria consisted of male and female participants without child bearing ability either due to menopause, documented hysterectomy, bilateral salpingectomy, bilateral oophorectomy, or bilateral tubal ligation, as well as age of at least 18 years, a body mass index of 30, or a body mass index of 27 with the presence of hypertension or dyslipidemia [1]

Some common side effects, such as nausea, vomiting, and diarrhea, were reported in higher numbers in the group taking a 1 mg dose compared to those on a lower dose

Frequency ranges from nightly to several times per week depending on clinical goals and patient response

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