For example: Certain amino acids are more sensitive to oxidation Peptides containing Trp residues may need even more protection from light and oxygen Acidic peptides and basic peptides may exhibit different stability profiles depending on the storage conditions Amino acid sequence can influence secondary structures and overall molecular stability (Sigma-Aldrich, 2023b
Structural modifications to the native amylin sequence enhance stability and prolong systemic persistence in research models
Conditions such as Crohn's disease, pernicious anemia, or a history of gastric surgery may increase the risk of B12 deficiency
Contact your GP, study team, or supervising clinician if fatigue: Is severe enough to significantly impair daily functioning, work, or personal care Persists without any improvement despite the dose stabilising Is accompanied by dizziness, fainting, or palpitations , which may suggest dehydration or electrolyte disturbance Occurs alongside unexplained weight loss beyond expected levels , pallor, or breathlessness which could indicate nutritional anaemia Is associated with low mood, persistent sadness, or loss of motivation , as these may suggest depression rather than drug-related tiredness Develops alongside jaundice, dark urine, or abdominal pain , which warrant urgent assessment to exclude hepatic or pancreatic causes Seek urgent medical attention (call 999 or go to A&E) if you experience: Severe, persistent upper abdominal pain, particularly if it radiates to the back and is accompanied by vomiting these are potential symptoms of pancreatitis and require immediate assessment [12] Chest pain, severe dizziness, confusion, or an inability to keep any fluids down For urgent advice that does not require emergency services , contact NHS 111 (online at 111.nhs.uk or by telephone)
