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For instance, the activation of the Nrf2/HO-1 pathway, the downstream upregulation of antioxidant enzymes, including SOD, GST and GPx, and the increased intracellular levels of glutathione have been proposed as common mechanisms underlying the antioxidant effects of these compounds

& Furst, D

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The purpose of this paper is to critically examine the inconsistencies of currently published data, examine the appropriateness of the current guidelines and to further educate anesthesiologists on the importance of informed perioperative assessment and management of these patients