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A diagnosis of rheumatoid arthritis is made

In a separate open-label extension study of ten patients, ages 13 to 18 years, who started a second course of Accutane 4 months after the first course, two patients showed a decrease in mean lumbar spine bone mineral density up to 3.25% (see WARNINGS: Skeletal: Bone Mineral Density)

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According to clinical studies, such as the STEP clinical trials, noticeable weight loss can be observed from about four weeks onward, with more significant results becoming evident within four to five months