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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

10.1111/j.1471-4159.2008.05605.x 75 WuY.ShiH.XuY.PeiJ.SongS.ChenW.et al (2022)

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