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AOD9604 and Energy Balance Research In obese ob/ob and lean C57BL/6J mice treated for 14 days via mini-osmotic pumps, AOD9604 significantly reduced body weight gain in obese mice, associated with increased in vivo fat oxidation and increased plasma glycerol levels as an index of enhanced lipolysis without the hyperglycaemia or reduced insulin secretion associated with intact hGH treatment

The anorexigenic effect of GLP-1 seems to be transduced via GLP-1R signaling in several areas of the brain, including both hypothalamic nuclei and the hindbrain

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