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But the moment its bottled, poured, stored, or exposed to air , it becomes part of an environment, one where bacteria, plastics, and outside elements can influence it

Impaired Spatial performance in cerebellar-deficient lurcher mice is not associated with their abnormal stress response

In certain embodiments, tonicity agents are added to the formulations described herein in an amount as to provide a practical osmolality of an otic formulation of about 100 mOsm/kg to about 1000 mOsm/kg, from about 200 mOsm/kg to about 800 mOsm/kg, from about 250 mOsm/kg to about 500 mOsm/kg, from about 250 mOsm/kg to about 350 mOsm/kg, or from about 280 mOsm/kg to about 320 mOsm/kg