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Nevertheless, enhanced abundance of DPP4 within adipose tissue of obese subjects may be involved in adipose tissue remodeling and substantially augments the lipolytic activity of enlarged adipocytes ( Moreover, dendritic cells and macrophages resident in visceral adipose depots exhibit an increased DPP4 expression in response to inflammation or in the obese state ( Adipose Tissue as Relevant Source of Circulating DPP4 Serum levels of sDPP4 are altered in many pathophysiologic conditions, including different types of cancer, allergic asthma, or hepatitis C ( Endocrine Effects of Soluble DPP4 Although there is clear evidence that increased circulating levels of sDPP4 are associated with hallmarks of obesity and type diabetes, such as whole-body IR, elevated BMI, and adipocyte hypertrophy, there are only few studies investigating the endocrine effects of sDPP4