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When compared with unfused receptors activated by saturated concentration (1 m) of GLP-1 or EX4, the fused receptors had slightly lower G-protein/cAMP signaling levels (~60% of fully activated unfused receptor, Figure 1c and d), but exhibited higher arrestin recruiting signaling levels (~150% of the fully activated unfused receptor, Figure 2b and c)

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It also serves as a required substrate for two important families of enzymes: the sirtuins, which help regulate healthy cellular aging, and the PARPs, which help repair damaged DNA

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