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Who should avoid GHK-CU Wilson's disease or copper metabolism disorders Active malignancies (until more research exists) Pregnancy and breastfeeding Known copper sensitivity or allergy Those unable to maintain sterile injection technique When uncertain, consult a healthcare provider familiar with peptide research

In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population

Glutathione is a tripeptide naturally synthesised in the liver, where it plays a role in antioxidant defence and cellular detoxification

[DOI] [PubMed] [Google Scholar] 222.Li JM