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In summary, autophagy mechanisms in PD involve multi-level autophagic flux disruption, lysosomal failure, mitophagy defects, and inflammatory cross-talk
52 In a large meta-analysis by Chiang et al involving 106,395 participants and 55 RCTs, GLP-1 RA therapy was associated with an increased risk of gastroesophageal reflux disease (GERD) compared to placebo, with a reported relative risk of 2.19 (95% CI: 1.483.25)
arginine and proline metabolism, cardiolipin biosynthesis, de novo triacylglycerol biosynthesis, glutamate metabolism, creatine deficiency, guanidinoacetate methyltransferase deficiency
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