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Besides vaginal birth and being heavily overweight, one of the causes for POP is diminished vaginal tissue stiffness through the reduction of collagen with age and hormonal changes 128,129

The detrimental effects of low-temperature preservation of ovarian tissue encompass ROS generation, DNA fragmentation, and caspase activation, which may result in damage to granulosa and stromal cells, oocyte degeneration, and follicular attrition

1 g kg 1 d-allulose to suppress food intake was not significantly altered at 0.5 h, but the suppression of food intake was mildly attenuated at 1 h and blunted at 2, 3, and 6 h (Fig