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Importantly, a recent retrospective study had found that GLP-1 RAs reduced suicidal ideation in large cohorts of overweight or T2D patients compared to non-GLP-1R agonist anti-obesity or anti-diabetes medications [Reference Wang, Volkow, Berger, Davis, Kaelber and Xu49]

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In native physiology, the six IGFBPs perform several overlapping regulatory jobs: they extend the circulating half-life of IGF-1, they create a reservoir of hormone that can be released as needed, they modulate the amount of free peptide available to receptors, and in some contexts they exert IGF-independent effects of their own