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The loss of DJ-1-mediated maintenance of the transsulfuration pathway could render microglia more vulnerable to ferroptotic damage, thereby linking its classical cytoprotective role in redox homeostasis directly to the emerging pathway of ferroptosis in neurodegeneration

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

(2020) dissect the functions of DHARs in a context of high-light stress, a condition that increases ascorbate oxidation as a protective mechanism and increases the ascorbate pool (Dowdle et al., 2007)