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Binding to this allosteric site can still influence the sensitivity and activity of the receptor, but could lead to drugs with fewer off-target side-effects, since GLP-1 is involved in many different metabolic signalling pathways

When GLP-1 agonists activate these brain receptors, they can influence dopamine and serotonin pathwaysneurotransmitters central to mood control

Evidence comes from preclinical animal models and community protocols

Prime/MRx is committed to using our real-world research to help our clients make informed benefit decisions for GLP-1 coverage as they navigate this dynamic landscape. For additional information and study design details, please refer to the year-two abstract