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LNP preparation All lipids used in this study were purchased from commercial vendors: DLin-MC3-DMA from Cayman Chemicals, Cholesterol from Sigma-Aldrich and DSPC and PEG2000-DMG from Avanti Polar Lipids

NHS access began in specialist weight management services from June 2025 for the highest-need patients, with tirzepatide prescribing incorporated into the GP Quality and Outcomes Framework from April 2026

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Clinical Evidence Behind Semaglutide for Weight Management The STEP trials (Semaglutide Treatment Effect in People with Obesity) enrolled over 4,500 patients without diabetes and demonstrated consistent weight loss ranging from 5% to 18% depending on dose and study cohort