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doi: 10.1177/1090820X13478630

Dysbiosis of gut microbiota in GBM based on randomisation studies Dysregulation of microorganisms, especially bacteria in the human body, leads to an imbalance in homeostasis, leading to immunosuppression and inflammation and modulating the therapeutic efficiency of drugs [167]

In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop

They are not approved for human or veterinary administration, are not evaluated by the FDA or EMA, and must not be used as drugs, supplements, or cosmetic products