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These include the development of next-generation glucagon-like peptide-1 receptor agonists (GLP1Ras), with their weight loss efficacy ranging from 12% to 15% for semaglutide and 20% for tirzepatide ( One salient concern regarding the use of GLP1Ras for older adults is their impact on skeletal health ( Given the rapid and increasing uptake of GLP1Ra-based therapies, coupled with the knowledge gap surrounding their impact on clinically relevant bone outcomes in older adults, we conducted an exploratory post hoc analysis of a pilot trial to explore the impact of 20 weeks of semaglutide use on bone density and turnover in older adults with overweight or obesity

The following adverse reactions have been reported: dryness and fissuring of paranasal and infraorbital areas, erythema, and stinging

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