semaglutide for alcohol use disorder Ozempic shown to reduce drinking in first trial in alcohol-use Ozempic Could Lower Urge For

A typical escalation schedule might involve starting at 1 to 2 mg weekly for the first month, increasing to 4 mg for the second month, moving to 8 mg for the third month, and reaching 12 mg only after establishing tolerance at lower doses

Preclinical models found that GLP-1 RAs reduce intestinal inflammation in dextran sulfate sodium (DSS)-induced colitis, by increasing IL-22 production by colonic IELs and several beneficial bacteria, including Firmicutes, Proteobacteria and Lactobacillus reuteri (93)

doi:10.1038/s41366-022-01213-0 232

Comparisons between the intervention and control groups for quantitative variables were conducted using independent-sample t-tests, while chi-squared tests were employed for qualitative variables