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Figure 3 Figure 4 As also underlined by the WHO Working Group in a paper published shortly after the 2018 Classification, the risk of an individual nevus progressing to melanoma has been estimated to be in the order of one in 33,000 or less per year (60)

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ROS, formed as a result of the use of contrast agents, can cause damage to the kidneys in several ways: the ionic contrast agent is hyperosmotic therefore can damage the tissue and lead to the accumulation of infected cells, polimorfonuclear leukocytes, at the injured place and to the release of ROS