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The discontinuation rate in clinical trials ranged between 20% and 50% within the first year, with GI intolerance being the primary reason

Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus

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Replacement effects are summarized in the first paragraph followed by our data interpretation in the second paragraph: Regression and pattern analyses revealed sequential kinetics for all mutants with an apparent common intersection point at the x axis (Supplementary Fig