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Research is ongoing, and there are signals from observational studies and reviews that GLP-1 therapies could influence neuroinflammation and neurodegenerative riskbut they are not currently indicated to treat Alzheimers or Parkinsons outside clinical trials, and some trials have not met primary endpoints

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Notably, elevated levels of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], a subclass of eicosanoids, activate the intracellular cation channel transient receptor potential vanilloid one and mediate endothelial dysfunction in DM (Otto et al., 2020)