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01 mechanism of action Melanotan 1 (MT-1, afamelanotide) is a synthetic linear analogue of native -MSH carrying a single Nle/D-Phe substitution that confers proteolytic stability and ~1000-fold potency increase at MC1R relative to the parent peptide

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Compounds (3,5-Odicaffeoyl-d-quinic acid and matesaponin-2 and linolenic acid exhibited significant elevations in GLP-1 levels [33]