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Acknowledgements We thank the nference engineering team for the development of the nference federated AI platform, and Patrick Lenehan for critical review and manuscript feedback

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Diverticular disease is another important consideration, particularly in older adults

Rarely, bupropion XL may cause some serious side effects, including: Increased risk of suicidal thoughts and behaviors Mood swings or changes such as agitation, panic attacks, or worsening symptoms of depression Extremely high blood pressure Manic episodes (overactivity, excessive happiness or sadness, and racing thoughts), especially in bipolar patients Increased risk of seizures Eye pain and blurred vision Serious, sometimes life-threatening allergic reactions (hives, swelling of your face, throat, tongue, or lips, chest pain, and shortness of breath) Contact your healthcare professional for medical advice about any possible adverse effects you experience while taking bupropion XL