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Hydroquinone and other skin lighteners work for those with dark pigmentation under their eyes (although do seek a doctors opinion first because usually darkness under the eyes is actually very thin skin with blood vessels showing through it and lightening agents will not help, but could hurt thin skin) 5

Megadoses of up to 2,000 mcg are considered safe in treating a B12 deficiency, but its best to avoid excessive amounts of any vitamins, especially when not needed

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However, retatrutide shows a higher overall rate of side effects and produces a more pronounced dose-dependent increase in heart rate due to glucagon receptor activation