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Vitexin alleviates streptozotocin-induced sexual dysfunction and fertility impairments in male mice via modulating the hypothalamuspituitarygonadal axis

In summary, GIP influences bone remodeling through an entero-endocrine-osseous axis and plays a role in coordinating optimal bone turnover in response to food intake, mainly during the day

The GnRH receptor is also found in certain cancers, and the reduction in circulating estrogen slows the growth of hormone receptor-positive tumors such as ovarian cancer 117 , prostate cancer 118 , and breast cancer 119,120,121

Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]