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Although manifestations of neurological dysfunction often point to TD and may sometimes accompany gastrointestinal beriberi (17, 64), it has been also noted that chronic mild deficiency may present with gastrointestinal symptoms under entirely normal neurological exams in well-nourished, non-alcoholic patients (6568)

As a single-mechanism agent, it suppresses appetite, delays gastric emptying, and enhances glucose-dependent insulin secretion

In addition, peptide therapy in general may lead to side effects related to the route of administration, which, in the case of ipamorelin, is subcutaneous injection