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Acute kidney injury: Reported in patients treated with GLP-1 receptor agonists, often related to nausea, vomiting, and diarrhea leading to volume depletion

Mechanism of Action: Semaglutide, the active ingredient in Rybelsus, is a GLP-1 receptor agonist that mimics the natural hormone GLP-1. It works by increasing insulin secretion, decreasing glucagon secretion, and slowing gastric emptying

When to contact a healthcare provider: Persistent vomiting, severe abdominal pain, signs of dehydration (dark urine, dizziness, dry mouth), or any symptoms that prevent normal daily activities

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