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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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Characteristics of nanoparticles Currently, several biomarkers, including antinuclear antibody (ANA), antiphospholipid antibodies and auto-antibodies (e.g., anti-Ro/SSA and anti-La/SSB), are used to support the diagnosis of autoimmune diseases [12]