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Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks

In another clinical trial of 140 participants, researchers found that semaglutide medications led to a loss of lean muscle mass in addition to fat loss

two to three times per day), can relieve nausea

doi: 10.1016/j.redox.2014.01.006