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Third, translational gaps between preclinical models and clinical practice are prominent: most therapeutic candidates (e.g., natural products and repurposed drugs) have only been validated in rodent models, with limited data on human renal tissue responses, optimal dosing windows, or potential drugdrug interactions in clinical settings (e.g., in patients undergoing kidney transplantation or cardiovascular surgery)

Unfortunately, there was no improvement among those with early DAMD, suggesting that antioxidant supplementation may not be able to slow or prevent the progression of AMD