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Thus, overwhelming lipid peroxidation by PUFA leads to an increased susceptibility to ferroptosis

Introduction Systemic lupus erythematosus (SLE) is defined as a chronic autoimmune disease with alternating periods of quiescence and disease flares ( SLE patients frequently develop lupus nephritis (LN) that can progress to end-stage renal disease (ESKD), with a risk between 10% and 30% at 15 years in patients with severe LN (classes III, IV, and V) ( According to the European Alliance of Associations for Rheumatology (EULAR) recommendations for disease management, the goals of SLE treatment are control of disease activity