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In 2023, a second piece of research sponsored by Eli Lilly (maker of Mounjaro and Zepbound) was published
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p 60 ml/min/1.73 m 2 than in patients with eGFR 60 ml/min/1.73 m 2
But what we wanted to understand is what theyre doing in the brain. Key findings GLP-1 drugs act not only on metabolic pathways but also on brain circuits linked to reward Researchers identified a pathway connecting the hindbrain, central amygdala and dopamine-producing neurons The drugs reduce not just hunger, but the desire for high-calorie, rewarding foods Findings may help explain both therapeutic benefits and side effects such as nausea or reduced pleasure Beyond appetite suppression GLP-1 receptor agonists were originally developed to treat Type 2 diabetes by improving insulin response, with weight loss emerging as a secondary benefit
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