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And it is already shaping fitness behavior

2.2 Mechanism of ferroptosis occurrence 2.2.1 Core regulatory pathways 2.2.1.1 System xc /GSH/GPX4 signaling as primary regulatory hub Ferroptosis regulation is widely recognized as primarily involving the constitutive inhibition of system Xc , which triggers a cascade leading to glutathione (GSH) exhaustion and GPX4 functional impairment

This upregulation is accompanied by an increase in the expression of c-myc and cyclin D1 proteins, crucial mediators of cell cycle progression

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