glp 1 for cardiovascular disease GLP-1RAs reduce deaths in patients with CKM comorbidity | Duke Clinical Research Institute posted on the topic GLP-1: A Game-Changer for Heart

Despite the controversies about the expression of GLP-1R in vascular smooth muscle and endothelial cells, studies have shown that GLP-1RAs have anti-proliferative effects on these cells, and also reduced oxidative stress and increased the production of nitric oxide (NO) (137, 138)

In our analysis, the subgroup with continuous lifestyle intervention showed significant weight regain, while the subgroup without the continuous lifestyle intervention did not

Additionally, an increase in the average heart rate of 1 to 4 beats per minute was observed in the semaglutide treatment group [16]

Rouphael NG, Paine M, Mosley R, Henry S, McAllister DV, Kalluri H, Pewin W, Frew PM, Yu T, Thornburg NJ, Kabbani S, Lai L, Vassilieva EV, Skountzou I, Compans RW, Mulligan MJ, Prausnitz MR, Beck A, Edupuganti S, Heeke S