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That seems to be the threshold where cognitive benefits kick in Creatine specifically shines cognitively under stress

In a prospective cohort analysis of 1,625 patients with stage III colon cancer enrolled in the CALGB/SWOG 80702 trial, individuals consuming highly pro-inflammatory dietscharacterized by frequent intake of red and processed meats, refined grains, and sugar-sweetened beverageshad an 87% higher risk of death compared to those adhering to anti-inflammatory diets rich in dark leafy greens, yellow vegetables, coffee, and tea

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Mice treated with GHK-Cu found the escape hole faster in a maze test, indicating better cognitive performance