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You can have the perfect protocol, but if your compound is impure, under-dosed, or contaminated with synthesis byproducts, your results will be meaningless at best and harmful at worst
under ad libitum feeding conditions
Nevertheless, these discussions in no way include the multifactorial nature of the disease processes encompassing IBD, and intentionally have not included potential implications of genetic predispositions, spontaneous immune deregulations, proteases, and microbiota, which are discussed in great detail in other great review articles
This dual action of promoting both MMP-2 and TIMPs might appear contradictory
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