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Treatment with cobalamin improves skeletal muscle dysfunction in patients with hyperhomocysteinemia 71 and reduces formalin-induced muscle pain

Abbreviations BBB: Blood brain barrier BSP: Bisulfite sequencing PCR CNS: Central nervous system COVID-19: Coronavirus disease 2019 CpG: Cytosine-phosphate-guanine DML: Differentially methylated locus HCY: Homocysteine MS: Multiple sclerosis PET-CT: Positron emission tomography - computed tomography ROCF: Rey-Osterrieth complex figure ROS: Reactive oxygen species RT-qPCR: Real time quantitative polymerase chain reaction SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TF: Transcription factor TFBS: Transcription factor binding site VCD: Visuoconstructive deficiency WHO: World Health Organization References Centers for Disease Control and Prevention (CDC)

Inflammation Research , 60(1), 7986

Patients leave our Doral consultation with a full kit (vials, bacteriostatic water for reconstitution, syringes, alcohol swabs, sharps container, and a written calendar) and are walked through the reconstitution and injection process live before they leave