Non-limitative examples of these salts are: chloride, bromide, orotate, aspartate, acid aspartate, citrate, acid citrate, magnesium citrate, phosphate, acid phosphate, fumarate, acid fumarate, magnesium fumarate, glycerophosphate, lactate, maleate and acid maleate, mucate, oxalate, acid oxalate, pamoate, acid pamoate, sulphate, acid sulphate, glucose phosphate, tartrate, acid tartrate, magnesium tartrate, 2-amino ethanesulphonate, magnesium 2-amino ethanesulphonate, methane- sulphonate, choline tartrate, tricloroacetate, and trifluoroacetate
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Glutamine is the main intracellular osmole of the brain
Collectively, these data suggest that MOTS-c modulates gene expression by downregulating senescence-related genes ( Grem1 and Cd38 ) and the aspartate/glutamate-related Mdh1b , while upregulating Epha5 , a key gene involved in -cell function