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This study is the first to examine the potential cardiovascular benefits of these drugs in a high-risk population of patients with both obesity and an autoimmune diseaseboth of which are associated with a higher risk of cardiovascular and blood clot events
Pooled analysis of Phase III trials indicate contrasting influences of renal function on blood pressure, body weight, and HbA1c reductions with empagliflozin
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8,9,2527,3439,68,69 The gliadin p31-43 peptide induces cellular stress, activates proliferative mechanisms of cryptic epithelial cells, drives enterocyte stress, induces a Ca 2+ surge (thus activating the CD autoantigen tTG), triggers a local pro-inflammatory storm, activates the NFB signaling pathway, inhibits CFTR (cystic fibrosis transmembrane conductance regulator, an ion channel protein), alters vesicular trafficking, activates the inflammasome platform, and reduces autophagy
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