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doi: 10.1038/nbt950

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The three common variants 2, 3, and 4 differ structurally by the presence of cysteine or arginine at two key positions: * APOE 2/2 Cysteine/Cysteine * APOE 3/3 Cysteine + Arginine * APOE 4/4 Arginine/Arginine The structural shift from cysteine to arginine alters the proteins shape and function