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EPCs contribute to postnatal vasculogenesis, and are recruited from the bone marrow to sites of injury via growth factors, cytokines and hypoxia-related signaling pathways, where they differentiate into mature endothelial cells and incorporate themselves into sites of active neovascularization [41, 51]

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By integrating results from the three machine learning methods, a Venn diagram was constructed to identify overlapping key genes, ultimately yielding GPX3 and MYC ( Figure 4F )