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Overall, the GHGHRIGF1 axis, part of the somatotropichypothalamicpituitary axis, has been commonly recognized in response to somatic growth, including cell proliferation, differentiation, division, and survival (Figure 1)

The mechanisms underlying an augmented GLP-1 response to intraduodenal glucose after Met (60 min) and Met (30 min) remain uncertain, but may reflect an effect of metformin on inhibiting glucose absorption in the upper small intestine, with consequent increased exposure of L cells to glucose more distally in the gut

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Exercise increases skeletal muscle MOTS-c approximately 11.9-fold