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Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]

Oral minoxidil, even at the low doses used for hair loss, carries a slightly different risk profile, including fluid retention, heart palpitations in rare cases, and unwanted body hair growth

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