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FIGURE 3 3.4 Lipidomics revealed that HUA increased glycerolipids in mice hearts To confirm whether HUA influence in vivo cardiac lipid metabolism, a HUA mice model was constructed according to our previously publication (Lin et al., 2022)

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National Institute for Health and Care Excellence (NICE) criteria for initiation of GLP-1 and GIP analogues is as follows: if triple therapy with metformin and two other oral drugs is not effective, not tolerated or contraindicated, consider triple therapy by switching one drug for a GLP-1 analogues for adults with T2DM who have a body mass index (BMI) of 35kg/m 2 or higher[15]

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