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For example, because STEP 1 trial eligibility criteria was used to identify NHANES participants, there may have been differences between the current study participants and STEP 1 participants, and therefore the weight loss and cardiovascular risk factor changes observed in STEP 1 may not be entirely translatable to our NHANES sample, Wong and colleagues wrote

Each puncture creates a potential entry point for bacteria

Metformin given in high doses to women with PCOS is more effective but exhibits multiple side effects

Conclusion IGF-1 DES exemplifies how minor structural modifications can dramatically alter peptide pharmacology