does semaglutide reduce blood sugar A diabetes drug. Then a weight-loss drug. Then a global blockbuster. Here's how GLP-1s went from helping manage to becoming one of medicine's biggest stories. [GLP-1, Ozempic, Wegovy, Mounjaro, diabetes Ozempic (semaglutide) is a prescription

doi: 10.3389/fphar.2026.1805842 Received 06 February 2026 Revised 30 March 2026 Accepted 06 April 2026 Published 29 April 2026 Volume 17 - 2026 Edited by Brian J Piper, Center for Pharmacy Innovation and Outcomes, United States Reviewed by Kenneth McCall, Binghamton University, United States Santenna Chenchula, All India Institute of Medical Sciences, India Youssef Soliman, Wright State University, United States Updates Copyright 2026 Zinzi, Gaio, Ruggiero, Mascolo, Riemma, Cipriani, Laino, Berrino, Rossi and Capuano

Many patients see weight loss within 4 to 12 weeks, with more pronounced results over 6 months to a year

18,19 Classification of DM DM is classified as T1D, T2D, GDM, monogenic DM, and other less common conditions, such as diabetes related to pancreatic disease, drug-induced, or rare insulin resistance and mitochondrial syndromes

Vasolidation GLP-1 receptor medications such as semaglutide also have vasodilatory effects on blood vessels (widening of blood vessels)