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Competing Interests The authors declare they no competing interests

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Moreover, UV radiation can activate the proopiomelanocortin (POMC) gene and thereby enhance the production of alpha-melanocyte stimulating hormone (-MSH) and adrenocorticotropic hormone (ACTH) which can lead to increased PKA and melanogenesis (Im et al., 2002)

128 Additionally, thalidomide inhibits M1 macrophage polarization by targeting the transcription factor IRF5, reduces the release of inflammatory signals, significantly reduces the secretion of the proinflammatory cytokines IL-12 and IFN-, and promotes intestinal mucosal healing