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The most common adverse effects relate directly to the medication's impact on stomach function and include: Nausea and vomiting affecting many patients initially, particularly during dose escalation Constipation or diarrhoea due to altered gut motility Abdominal discomfort or bloating from delayed gastric emptying Reduced appetite often the desired therapeutic effect Early satiety feeling full after eating very small amounts These effects are typically most noticeable when initiating treatment or increasing the dose

DOI: 10.1002/eji.1830261229 40

Oct 20: Sanofi and Regeneron suffered a rare defeat with Dupixent this weekend as the FDA issued a Complete Response Letter to their supplemental Biologics License Application in chronic spontaneous urticaria, an inflammatory skin condition that leads to debilitating hives

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